Biofilm: problem and Prevention

Biofilm: Problem and Prevention


One of the most challenging infection prevention and control problems (that its prevention is the key) is competing the biofilm formation either monospecies or multispecies even it can be prokaryote or eukaryote that minimize the ability to detect the antibiotics in the microbiology laboratories plus decrease the effect of antibiotic treatment as it has the ability of at least 100 to 1000 fold increase ability to resist antibiotic treatment and prevent the penetration of surface disinfectant for the environmental issues.

Biofilm Problem and Prevention

Biofilm Problem and Prevention

Biofilm can be defined as: “ a microbially derived sessile community characterized by cells that are irreversibly attached to a substratum or interface , and embedded in a matrix of extracellular polymeric substances that produced, and exhibit an affecting phenotype with respect to growth rate . “Biofilms developed in a 3D architecture that is well defined they are associated with chronic infections included otitis media, periodontitis, native valve endocarditis, cystic fibrosis, prostatitis, sinusitis, necrotizing fasciitis, osteomyelitis, infectious kidney stones, and biliary infections plus infections related to tissue and indwelling medical devices interfaces


Treatment and management of biofilm-associated diseases is complicated, often hard to detect in their chronic association, and difficult to be treated by traditional antimicrobial due to resistance pattern of the formation germs and close attachment preventing penetration . Several features are often considered when designing and implementing new antimicrobial strategies directed toward biofilm diseases. Prevention is better than cure considered the golden key to overcome the biofilm formation

Catheter removal could be the most effective treatment and is often the treatment of choice. For urinary catheters, this is can be the best option as usually the best catheter is the one you didn’t indwell and it has to create a clear protocol for the indication of indwelling urinary catheter    However, this may be impossible for central venous catheters, especially if it means loss of the only available access site, or if it may lead to a difficult procedure based on the patient’s clinical situation but close monitoring for the clinical situation in order to remove the central line once the patient situation is indicated.

A new trends for prevention strategy: abiotic surfaces (IMDs) coated with anti-infectives against selected “marker” organisms, essential for biofilm 3D integrity and structures that called (“smart devices”) e.g. Silver coated catheters; and (2) biotic surfaces colonized with Replacement Therapy organisms, or Probiotics, that reinforce the beneficial normal flora (NF) of the sites at risk that called (“smart probiotics”) or site specific.



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